∵a>b>c>0,∴2a2+ 1 ab + 1 a(a?b) -10ac+25c2=a2+ 1 b(a?b) +(a?5c)2≥a2+ 1 ( b+a?b 2 )2 +(a?5c)2=a2+ 4 a2 +(a-5c)2≥2 a2? 4 a2 +0=4.当且仅当a=2b=5c= 2 时取等号.因此2a2+ 1 ab + 1 a(a?b) -10ac+25c2的最小值是4.故答案为:4.